I do not understand why these MD around the world are putting ppl on Tramadol (Ultram) combined with Cymbalta when there can be drug interactions. My MD took Tramadol away from me the min. I got put on Cymbalta d/t it even came up on her computer flagged as interactions. For anyone on this combo plz be careful et watch for what they call "serotonin syndrome" interactions can range from conf., hallucinations, seizure, extreme changes in blood pres., increased heart rate, temp., excessive sweating, blurred vision, muscles stiffen or spasm, nausea/vomiting to name a few. So if anyone is on this combo be aware:( Just an FYI...God bless et gentle hugs to everyone

Moorhope yes Tramadal can interact with antidepressant. If you take Cymbalta...not suppose to take tog. And Bushbaby yes if you take something for too long you can build like a tolerance to your medication et it will not work/help as well as it use too. Like Jami stated with this disease/syndrome we all have to find the perfect combo that works for each of us cuz everyone's body is diff. Hope you the best et hope you find the right combo for you so you can at least be pain free. God bless et gentle hugs

I think the trouble is my body has built up a tolerance to things.... what happens then. .. I feel like I'm in constant pain x

Best thing to do with the ones that cause insomnia, instead of taking at night/bedtime, try around 6/7ish instead. I found that helped me alot :)

i'm on tramadol and gabapenten. have been on gabapenten for years twice a day. tramadol is very light and it hasn't been classified as an opioid until recently. i've been told by other dr that it's just a bit better than an OTC product like advil. now this new classification.