I just got my prescription for LDN, but haven't started it yet. I can keep you posted.

Hi Steve3, drugs.com has all sorts of reviews on different medications. Below link:

https://www.drugs.com/comments/naltrexone/for-f...

This is one of the most recent review:
Taken for 1 to 6 months November 12, 2024
"I had chronic fatigue syndrome and fibro for around 30 years. Tried LDN at 4.5 mg twice without success. Decided to try it one more time. Built up from 2 mg a day to 4 mg a day. Read about someone taking 50 mg naltrexone a day, and it relieved their fatigue. The 4 mg helped me but didn't relieve my fatigue. Dr. agreed to increase my dose to 25 mg. So much improvement now. I may ask to go up to 50 mg a day, but at this point, I'm really happy with results so far. Had some nausea while starting at 2 mg, but none now."

10 / 10

Naltrexone has an average rating of 7.0 out of 10 from a total of 68 reviews for the off-label treatment of Fibromyalgia. 63% of reviewers reported a positive experience, while 25% reported a negative experience.

Everyone responds differently to it Steve. Only way to know if it’s right for you, is to try it.

I was just talking with someone on the Stuff That Works site about this. I have seen a lot on LDN on that site but I don’t know anyone personally taking it. I don’t know anyone personally with fibromyalgia to begin with. Anyway, the person I was speaking with said it takes about 6 months to really have an effect and that you take it at such a low dose as to not get addicted. (1mg daily- increasing to 3mg after a few years). I feel like it’s worth it to try, I want to try because the FDA approved drug for fibromyalgia has so many side effects and the rule of thumb by doctors is to just keep increasing the dose if you’re not having any positive effects which make it harder to get off. My pharmacist confirmed this. I would say the most challenging thing is to get our doctors to prescribe LDN in the first place as it’s not an FDA approved treatment (which I don’t have much stock in that anyway) so the doctors are unfamiliar with prescribing it for fibromyalgia. If you have the opportunity to try it, if it was me, I would. I keep hearing positive things about it. Just know it takes many months before you notice a difference.

I had a three month, very expensive trial with titration up. Never reached a sweet spot, in fact, made the Fibro worse, but it was worth a try. Going through a compound pharmacy was a bear. You're better off having your primary physician write for a higher dose, then titrate it yourself by pill splitting and adding H2O to turn it into a solution to save $$. Good luck. 💜